منابع مشابه
Organelle targeting: third level of drug targeting
Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug administration is the lack of target-specific affinity toward a pathological site, resulting in systemic toxicity and innumerable other side effects as well as higher dosage requirement for efficacy. An attractive strategy to increase the ther...
متن کاملDrug targeting to lysosomes.
1982). It is not clear how the rate of entry into lysosomes themselves is affected, but it may be retarded. The situation is even more obscure in the case of entry into lysosomes by autophagy. There are some indications of abnormalities in endogenous protein breakdown, and in perhaps of the lysosomal component thereof, in I-cell disease (Cockle & Dean, 1984). Similarly, Sameshima et al. (1981) ...
متن کاملDrug Targeting and Encapsulation
1 In the past few years, considerable advances of basic and application researches have taken place in the field of pharmaceutics. The newly recognized research thrust on nanoand microencapsulation is expected to have a revolutionary impact on the human health. To do this, considerable interest has been devoted towards the design of new drug delivery systems with the aim to specifically target ...
متن کاملDrug delivery and drug targeting: Drug targeting using thermally responsive polymers and local hyperthermia.
We report a new thermal targeting method in which a thermally responsive drug carrier selectively accumulates in a solid tumor that is maintained above physiological temperature by externally applied, focused hyperthermia. We synthesized two thermally responsive polymers that were designed to exhibit a lower critical solution temperature (LCST) transition slightly above physiological temperatur...
متن کاملMultifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery.
A new type of multifunctional polymeric micelle drug carrier for active intracellular drug delivery was prepared and characterized in this study. The micelle is a nano-supramolecular assembly with a spherical core-shell structure, and its surface and core were modified with piloting molecules for cancer cells and pH-sensitive drug binding linkers for controlled drug release, respectively. In or...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Open Schools Journal for Open Science
سال: 2020
ISSN: 2623-3606
DOI: 10.12681/osj.22588